Although the immunogenicity of human - rat chimeric antibodies is reduced, Human anti - Murine Antibody reactions are still produced.

尽管人 - 鼠嵌合抗体与鼠单克隆抗体相比外源片段的比率和免疫原性都有所降低, 但是仍然可产生人 抗 嵌合抗体反应.

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However, the property of provoking strong Human anti - Murine Antibody ( HAMA ) immune responses restricts their application clinically.

但是, 鼠源抗体极易引起人体排异反应的特点限制了这些抗体在疾病治疗领域的应用.

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