The coupling reaction between the difficult sequence Fmoc - Arg ( Pbf ) - OH and H - Pro - Trt resin was investigated.
着重研究了 Fmoc -Arg ( Pbf ) -OH与H -Pro-Trt 树脂的缩合反应.
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METHODS: Radioactive microsphere technique ( RMT ) was used in the measurement and calculation of PBF.
方法: 采用放射性生物微球技术,测量并计算犬牙髓组织的PBF值.
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Fmoc, Boc and Pbf were used respectively to protect α - amido, side amido and side guanidine group.
对于α-氨基仍采用Fmoc保护策略, 侧链氨基用二碳酸二叔丁酯引入叔丁氧羰基来保护,侧链胍基用酸敏感保护基2,2, 4,6,7-五甲基二氢苯并呋喃-5-磺酰基来保护.
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