Methods of disulfide formation in peptide synthesis are reviewed in this paper.

综述了多肽合成中几种形成二硫键的方法.

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The synthesis of cyclo ( - Ab 7 - Aib - Phe - D - Pro - ) which uses solid phase peptide synthesis with N - Fmoc protection is faild.

本论文尝试用固相法氨基酸N端Fmoc保护策略合成cyclo ( -Ab7-Aib-Phe-D-Pro- ).但是最终产物经ESI-MS分析不是目标产物,故改用液相法合成目标化合物.

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Finally , cyclo ( - Ab 7 - Aib - Phe ( 2 - Me ) - D - Pro - ) is successfully prepared by using liquid phase peptide synthesis with Boc protection.

Boc -Ab7-Aib-Phe( 2-Me)-D-Pro-OBzl脱除两端保护得到线性肽链经过环化得到目标产物cyclo ( -Ab7-Aib-Phe ( 2-Me ) -D-Pro- ),收率0.8%.

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