Don't back up the moment you run up against a little difficulty.

不要遇到一点困难就打退堂鼓.

《现代汉英综合大词典》

This is one of the most puzzling cases I have ever run up against.

这是我经手的最难办的案件之一.

辞典例句

When our principles run up against our interests, which should we adhere to?

当我们的原则和自身利益互相冲突时, 我们应该服从哪一方 呢 ?

互联网

We may run up against some difficulties but we are confident of overcoming them.

我们可能要碰到一些困难,但是我们有信心克服它们.

互联网