This paper summarized modifying molecular structure and relation between structure to activity of camptothecin.

本文对结构修饰和构效关系做一简要综述.

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Twelve 20 - hydroxyl ester analogues of camptothecin were prepared and evaluated in vitro antitumor activity.

为了改善取代喜树碱的溶解性、抗肿瘤活性和毒副作用,设计合成了十二个新的取代喜树碱20-位羟基酯衍生物.

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Objective The anti carcinoma pattern of hydroxy camptothecin ( OPT ) is estimated and guided to clinical medication.

目的:预测羟基喜树碱 ( OPT ) 的抗癌谱,指导临床用药.

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Camptothecin was isolated in 1966, but its use was hampered by its poor water solubility.

喜树碱早在1966年就已经被分离出来, 由于水溶性差而阻碍了对它的使用.

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Method Topotecan hydrochloride was synthesized from camptothecin by improved hydrogenation oxidation and the Mannich reaction.

方法以天然产物喜树碱为原料,经氢化还原、化制得中间体10羟基喜树碱,再与双(甲氨基)烷反应制备盐酸拓扑替康.

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The technological process for producing camptothecin by using dendrophilous leaf and seed as raw material.

本发明涉及一种以喜树叶及种子为原料,生产喜树碱的工艺方法.

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