Loteprednol etabonate was synthesized through oxidation, acylation, hydrolysis and chloromethylation from the starting material prednisolone.

以泼尼松龙为原料,经氧化 、 酰化 、 水解成盐、氯甲基化成酯制得氯替泼诺.

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P - methoxybenzeneacetonitrile was prepared in 34.8 % yield starting from anisole, via chloromethylation, cyanogenation and fractional distillation.

以苯甲醚为原料,经过氯甲基化, 氰化反应后, 通过精馏获得对甲氧基苯乙腈,总收率为34.8%.

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